منابع مشابه
Synbiotics, Surgical Infection and Colonization Resistance
In our recent randomized controlled study to assess the effect of perioperative oral administration of synbiotics on surgical outcome in patients undergoing laparoscopic colorectal resection, the efficacy of synbiotics as a treatment to reduce the incidence of infectious complications was not validated. However, this study incorporated molecularbased methods and a large sample size, and microbi...
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Antibiotics strongly disrupt the human gut microbiota, which in consequence loses its colonization resistance capacity, allowing infection by opportunistic pathogens such as Clostridium difficile. This bacterium is the main cause of antibiotic-associated diarrhea and a current problem in developed countries, since its incidence and severity have increased during the last years. Furthermore, the...
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Carlos Molina-Santiago,1 Zulema Udaondo,1 Anelis Marin,1,2 Adela García-Salamanca,1 Carmen Michán,3 Craig Daniels,4 Lázaro Molina1,5 and Juan Luis Ramos1* Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, C/ Prof. Albareda, 1, E-18008 Granada, Spain. University of Curitiva, Curitiba, Brasil. Universidad de Córdoba, Campus de Rabanales, Dept. of Biochemistry and ...
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TolC and its homologues are outer membrane proteins that are essential for the transport of many molecules across the cell envelope. In this study we characterized the gene encoding Vibrio cholerae TolC. V. cholerae tolC mutants failed to secrete the RTX cytotoxin, were hypersensitive to antimicrobial agents, and were deficient in intestinal colonization.
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Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic VRE infections and patient-to-patient transmission. Although obligate anaerob...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1994
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.38.3.409